Environment

EPA Awards $32 million to fund four Clean Air Research Centers at universities conducting cutting edge air pollution research

Submitted by Norm Roulet on Mon, 03/07/2011 - 18:59.

EPA Awards $32 Million to Understand Health Impacts of Air Pollution

WASHINGTON -- The U.S. Environmental Protection Agency has awarded $32 million to fund four new Clean Air Research Centers at universities conducting cutting edge air pollution research. The research will focus on the impacts of air pollution mixtures on people’s health. It is important to understand the health risks associated with exposure to multiple air pollutants because people are exposed to more than one pollutant at a time.“These centers are critical to understanding how to improve air quality and protect Americans’ health from complex mixtures of air pollutants,” said Dr. Paul Anastas, assistant administrator for EPA’s Office of Research and Development. “The centers will focus on important scientific questions remaining in air research.”

Energy Matters, the quarterly newsletter for the U.S. Department of Energy's Industrial Technologies Program (ITP)

Submitted by Norm Roulet on Mon, 03/07/2011 - 18:44.

Winter 2011 Issue of Energy Matters Now Available

Energy Matters, the quarterly newsletter for the U.S. Department of Energy's Industrial Technologies Program (ITP), provides in-depth articles to help industry professionals save energy, reduce costs, and increase productivity.

The Winter 2011 issue includes the following:

EPA Seeks Comment on Their Environmental Justice Action Development Process Guide - Close of Public Comment Period April 8, 2011

Submitted by Norm Roulet on Thu, 03/03/2011 - 19:07.

Environmental Justice - It ain't a RACE thing - it's an INJUSTICE thing

As thoroughly documented on realNEO, over a course of many years - and now being thoroughly addressed by the EPA through their courses of action - Cleveland has environmental justice problems to solve.

Right now - through April 8, 2011 - the EPA is asking for your help determining how they carry out that responsibility, as they want public comment on THEIR Guide to Providing Environmental Justice for YOU.

As quoted from the EPA's Interim Guidance on Considering Environmental Justice During the Development of an Action, introduced and linked below: "Environmental justice (EJ) is central to the Agency’s mission and is the responsibility of everyone at EPA".

Peak Drupal 2011: Real Drops of Open Source Alternate Energy to Fuel and Feed Villagers in "The Social Network" Desert

Submitted by Norm Roulet on Wed, 03/02/2011 - 15:00.

Screen Shot of White House Gov website March 2 2011

At the beginning of the 21st Century - a time when the pace of global evolution was certain to be astounding in every way, in accelerating change each day - especially as driven by transformational new Information Technologies (IT) and services - a serious, young college computer science student wrote some historic collaboration software, in his dorm-room, to help his fellow students communicate more effectively in their evolving, un-tethering, socially-networked world, and that software has been helping citizens freely interconnect with greater impact each day since, to save the world.

The early days of this software are beloved, in real geek-lore:

In 2000, permanent Internet connections were at a premium for University students, so two students set up a wireless bridge between their student dorms to share one of the students' ADSL modem connection among eight students. While this was an extremely luxurious situation at that time, something was missing: There was no means to discuss or share simple things.

This inspired the other student to work on a small news site with a built-in web board, allowing the group of friends to leave each other notes about the status of the network, to announce where they were having dinner, or to share some noteworthy news items.

The software did not have a name until the day after that student moved out after graduation. The group decided to put the internal website on-line so they could stay in touch, keep sharing interesting findings, and narrate snippets of their personal lives. While looking for a suitable domain name...

Mr. Wolstein, Please hold off on using the Forum Architects' plans for your redevelopment in the Flats, as much has improved

Submitted by Norm Roulet on Tue, 03/01/2011 - 04:44.

Sunset over Lake Erie from Whiskey Island, and a nearly perfect Summer's day. Dedicated to Citizen Ed Hauser.
Sunset over Lake Erie from Whiskey Island, on a nearly perfect Summer's day. Dedicated to Citizen Ed Hauser.

Dear Mr. Wolstein,

Please hold off on using the Forum Architects' plans for your redevelopment in the Flats, as much has improved in the prospects for this city and region since they were conceived - there is new energy, life and opportunity coming into Cleveland that will improve the prospects for this most important historic site that I've been vocal in my disappointment to see go.

As you are moving forward in new directions, Cleveland and regional leaders including myself must move forward in many new directions previously inconceivable. As such, planning needs frequent re-visioning - and may in fact be open sourced, real-time and community enabled with world class information technology, which we'll be developing more of in Northeast Ohio in the future.

Most significant, we are in the process of removing from our community the dangerous pollution emitted from the coal burning at FirstEnergy Lake Shore (already decommissioning), MCCO, in University Circle, and Cleveland Thermal, next door to your site (your greatest liability, easily made an asset), and the outrageous environmental injustice from Mittal and some other industrial operations - and the direct and fugitive emissions from the mobile pollution sources servicing them - ships, trains and trucks  - that are just not safe for dense urban neighborhoods, which we must save and restore. There are economically viable solutions to all these challenges - it does not need to be this way!

Dear Mr. Mowry, Chief Information Officer, Cuyahoga County, Ohio - Welcome Home.

Submitted by Norm Roulet on Mon, 02/28/2011 - 17:17.

Broward County homepage February 28, 2011

Dear Mr. Mowry, Chief Information Officer, Cuyahoga County, Ohio:

Welcome Home.

Without a doubt, you hold the most opportune and important office in the region, today, and I wish you great success.

Be Afraid, Be Very Afraid!!!!!!!!

Submitted by Charles Frost on Sun, 02/27/2011 - 23:39.

We Don't Need Alternative Energy! - Global Warming Solution - Easy!!!!!

(A) Small Nuclear War Could Reverse Global Warming for Years

http://news.nationalgeographic.com

( categories: )

Freshwater Cleveland

Submitted by lmcshane on Sun, 02/27/2011 - 15:06.

Broken fire hydrant at Pearl and Denison 500 yards from school
A walk around the neighborhood today revealed an infrastructure in shambles. 

President Obama--we need a Civilian Conservation Corp.  We need to fix America.  We are squandering precious natural resources and our future.  This fire hydrant is less than 500 yards away from a school on Denison Ave. and less than a block away from Cleveland Fire Station #20 at Archwood and SR 42/Pearl Rd..

( categories: )

Dear Governor Kasich: Show REAL NEO You Are Serious About Ohio's Future By Ending The $3.5+ Billion ODOT I-90 Bridge Fiasco Here

Submitted by Norm Roulet on Sun, 02/27/2011 - 07:10.


Cleveland Institute of Art BA and Kent State University Cleveland Urban Design Collaborative planning Master Joseph Stanley
had a more intelligent design for the future of Cleveland than the leaders of our community have embraced - BIG SURPRISE... he's not an idiot!

Dear Governor Kasich:

Show REAL NEO You Are Serious About Ohio's Future By Ending The $3.5+ Billion ODOT I-90 Bridge Fiasco Here!

I'm sure, with little effort, you may find leadership in Columbus and the great-big-real-world to brief you on the runaway stupidity and corruption surrounding the "planning" by corrupt "idiots", as you say, at Ohio Department of Transportation (ODOT), to replace our poorly maintained I-90 bridge over the polluted Cuyahoga River into Downtown Cleveland's Innerbelt "Trench". My good friend Ed Hauser was leading the battle against this stupidity before he was killed by pollution exposure here, and I am asking you to take his place fighting for our citizens. The war is well documented here on realNEO - and nowhere else on Earth. Google "realNEO ODOT Dream" or search within realNEO for links to ODOT, Bridge, Cleveland and Hauser.

To speed-up your assessment, I include below some links I have surfaced from our years of battling government stupidity, corruption and incompetence with ODOT here, as well as my most recent posting on realNEO about this matter.

Demonstrating leadership of Cleveland Plain Dealer, Clinic and Cleveland are unintelligent, compromised and bad for our health

Submitted by Norm Roulet on Sat, 02/26/2011 - 16:53.

FURTHER demonstrating the leadership of the Cleveland Plain Dealer, Cleveland Clinic and Cleveland are unintelligent, compromised and bad for people's health... read how they define hazards to public health without addressing air pollution and lead poisoning, still again.

CON-MEN, WORKING FOR KOCHS!

The best line in this article is "What Dr. Eric Bieber, chief medical officer at UH, likes about resolution is that it will make it easier for people to do what's right." Yes, that would seem easier to someone who just had his coal power plant shut-the-F-down. That sure as hell wasn't easy on citizens!

Why must all the wrong people live long, healthy lives while we poor victims die of the toxins of their rich? I pray for divine intervention in the lives of these evil leaders here... as clearly they drink too much Tea and huff too many lead and coal fumes to think clearly themselves... especially if they put Cimperman in charge of OUR PUBLIC HEALTH!

Can you say take me to the Mayo Clinic please!

If there are any concilpeople with brains still functioning in Cleveland (Cummins), please bring up the obvious in the Council hearings on our leadership's stupidity - IT'S THE LEAD POISONING AND AIR POLLUTION STUPIDS - or face the consequences!

All You Apple Junkies... You are Koch-Heads: "Rupert and Steve Bromance"... "Rupert Murdoch and David Koch Collude"

Submitted by Norm Roulet on Sat, 02/26/2011 - 15:37.

Apple adicts are the most smug and unsophisticated computer uses on Earth - hooked on over-priced, under-performing, locked-in eye-candy so they may live without thinking about the real world of technology, or anything else that matters, it is confirmed - the I-Me generation funds The Tea Party. While Appleoids tend to think of themselves as hip and cool, they are quite the opposite, streaming their money into the coffers of Rupert Murdoch, the Kochs and their Fox Tea Party agenda against humanity. Didn't know that... perhaps you need to ditch your I-Pad and it's Fox News lock-in and be real...

"In fact, for two men who outwardly have little in common, save for spectacular wealth, Murdoch and Apple boss Steve Jobs are awfully simpatico these days"... "Jobs' strategy of using other people's cheap content to drive sales of expensive Apple devices also dovetails nicely with Murdoch's historic willingness to engage in price wars with competitors he regards as less deep-pocketed, more susceptible to investor pressure, or simply less committed than he"... "Rupert and Steve: a bromance for the ages."

Making Jobs, Apple Computer Corporation and Appleoids partners with Murdoch, the Koch Brothers and their Tea Party in ruining the world... and it is Apple users fault for supporting that with their money... unless they like Tea with their apples...

"While Fox News feeds its rabble the anti-union line, Murdoch's Wall Street Journal columnists front for Koch's Americans for Prosperity and coddle elite investors"... "The informal partnership between billionaire David Koch, whose campaign dollars and astroturf group, Americans for Prosperity, have fomented the Wisconsin crisis, and billionaire Rupert Murdoch, is profoundly ideological -- the ideology being the exponential enrichment of the two men's heirs, all dressed up in the language of libertarianism and free enterprise"... "Ginning up the right-wing rabble is a Fox News specialty. Glenn Beck is more than a talk-show host; he's Rupert Murdoch's community organizer"... "When Rupert Murdoch added the Wall Street Journal to his holdings in 2007, he became the titular boss of Moore, one of David Koch's favorite sons. Perhaps it works like one of those royal marriages of yore. With those bonds, the lord of right-wing media cemented, perhaps, his standing in the realm of the man who would be king of the world."

Dear Very Reverend Lind and supporters of Trinity Cathedral: Praying for your health, happiness and wisdom

Submitted by Norm Roulet on Fri, 02/25/2011 - 15:14.

As I informed the Very Reverend Lind, of Trinity Cathedral, I am posting this outreach for the help of her good people to move Cleveland Thermal and so Cleveland beyond coal. Please reach out to these friends of the community with your words of support for a cleaner, safer, healthier, more prosperous Cleveland and NEO for all, beyond coal.

Dear Reverend Lind and supporters of Trinity Cathedral:
Norm Roulet <norm [at] realneo [dot] us>     Fri, Feb 25, 2011 at 4:01 PM
To: tlind [at] dohio [dot] org
Cc: Nachy Kanfer <nachy [dot] kanfer [at] sierraclub [dot] org>
Dear Very Reverend Lind and supporters of Trinity Cathedral:

I appreciate your presence and good work in this community, and know you are prominent preachers for goodness, on a good Earth.

It has come to my attention that Trinity Cathedral is a customer of the Cleveland Thermal coal steam plant in the Flats, providing excessively-polluting utilities to your facilities on Euclid Avenue - that is featured on their website at http://www.clevelandthermal.com/services/case-studies

Cimperman for Congress 2008 - Top Donors - featuring Charles Evans from Dominion Cleveland Thermal for $2,000

Submitted by Norm Roulet on Fri, 02/25/2011 - 13:52.

Cimperman for Congress 2008 - Top Donors - featuring Charles Evans from Dominion Cleveland Thermal for $2,000 - I assume the DiSanto, Frederick D. of Ancora Advisors LLC listed here for $2,300 is the same Ancora of Grenwich, Connecticut that bought Cleveland Thermal from Dominion in 2004:

RICHMOND, Va., July 1 /PRNewswire/ -- Dominion (NYSE: D) announced today that it has agreed to sell Dominion Cleveland Thermal to Ancora Management LLC of Greenwich, Connecticut. Closing is expected in the fourth quarter of 2004. Terms of the sale were not disclosed and the sale is subject to regulatory approval.

Look at all the other corrupting industrial and developer scum on Cimpermans buy-list who have been screwing Cleveland... wonder what each one wanted in return for their $1,000s... lucky Cimperman lost by a mile. Time to rid Cleveland of the power of all these self-serving, citizen-killing parasites forever!
 

Top 100 Donations/Contributions in the '08 Election Cycle to
JOE CIMPERMAN FOR CONGRESS

Name/
Location
Employer/
Occupation
Contribution
$ Amount
Primary/
General
Date
Adams, Al T.
Cleveland, OH
44114
Baker/Attorney $2,300 P 02/12/2008
Alexander, Anthony
Akron, OH
44308
FirstEnergy Corporation/President $2,300 P 02/28/2008

Cleveland Thermal Energy and The Plain Dealer Publishing Company... I know the Pieces Fit!

Submitted by Norm Roulet on Fri, 02/25/2011 - 12:12.

An ambient film of real NEO people walking, shot from outside the Cleveland Plain Dealer newspaper headquarters, featuring late afternoon activity in the newsroom as seen from Superior Avenue, Cleveland, Ohio, realNEO... "Schism" by TOOL is playing in the background, accompanied by the sounds of realNEO..

I've often wondered why the Cleveland Plain Dealer has been so disrespectful and harmful to me - I believe the following documents will explain - The Cleveland Plain Dealer is a Cleveland Thermal customer and so Cleveland Environmental Justice criminal - I know the Pieces Fit!

Document Record

View Image
Date Filed:  Document Type:  Number of pages:  Case Numbers:  Summary: 
2/5/1997 7:20:03 AM
TX-Text
000012
89-0362-HT-AEC
Alternate energy steam service agreement between Cleveland thermal Energy and The Plain Dealer Publishing Company, filed on behalf of applicant by S. Howard. (12 pgs.)

How insulting is it for the Mayor of Cleveland to attack citizens for depression, when that is caused by HIS lead poisoning?

Submitted by Norm Roulet on Thu, 02/24/2011 - 16:26.

Mayor Jackson has been reported to believe the problems with Clevelanders and so his Great City are all in our heads - we're depressed and have a bad attitude... get over it. In response, Cleveland leaders have initiated a variety of "don't worry be happy" "Believe in Cleveland" programs, like their latest "Happiness Virus" initiative by a group of consultants associated with the Cleveland Clinic leadership.

Unfortunately, MEDICAL SCIENCE finds this ridiculous outlook and strategy ignores the cause of citizens' very real depression here - lead poisoning.

The real science of the Archives of General Psychiatry "looked at 1,987 adults ages 20 through 39, finding that those with the highest blood lead levels were more than twice as likely to suffer a major depressive disorder and nearly five times as likely to suffer from panic disorders as those without elevated blood lead levels. The study is a rare look at how lead exposure can affect adults, as most research to date has been focused on the side effects of lead on children."

Half of world’s population could face climate-driven food crisis in second half of the century

Submitted by Norm Roulet on Thu, 02/24/2011 - 13:09.

From Climate Progress:

Half of world’s population could face climate-driven food crisis in second half of the century - Science study warns: “Ignoring climate projections at this stage will only result in the worst form of triage.”

Posted: 24 Feb 2011 06:41 AM PST

[I'm on travel, so I'm updating this timely 2009 post on food insecurity.]

The quote above is the powerful final sentence from a 2009 study in Science, “Historical Warnings of Future Food Insecurity with Unprecedented Seasonal Heat.”  The University of Washington news release release explained:

Rapidly warming climate is likely to seriously alter crop yields in the tropics and subtropics by the end of this century and, without adaptation, will leave half the world’s population facing serious food shortages, new research shows….

“The stresses on global food production from temperature alone are going to be huge, and that doesn’t take into account water supplies stressed by the higher temperatures,” said David Battisti, a University of Washington atmospheric sciences professor.

Yes, this 2009 study is a serious underestimate of the speed and scale of likely impacts for two reasons.

Dear Sierra Club President: Please Add Cleveland State University to your "Campuses Beyond Coal" Campaign and Begin Organizing!

Submitted by Norm Roulet on Thu, 02/24/2011 - 10:47.

Dear Sierra Club President and Nachy Kanfer - Campuses Beyond Coal:

Please Add Cleveland State University to your "Campuses Beyond Coal" Campaign and begin organizing against their primary energy provider, the astoundingly deadly, coal-polluting, private-investor-owned Cleveland Thermal coal furnace in the Cleveland Flats!

Cleveland State University (CSU) is the largest customer of Cleveland Thermal, and so must take a lead in moving this community beyond coal.

I don't imagine President Obama realized this sad situation, prior to his recent visit to Cleveland to meet with small business leaders and government representative at CSU about "jump-starting" our local economy, killed by pollution. I'm sure if he knew he was supporting environmental injustice here, in that way, he would have chosen a more socially-just venue to promote. Cleveland State University is not included in your "Campuses Beyond Coal" campaign, and should be added and activated immediately - Cleveland Thermal is one of the largest polluters in America - we must bring this to light and move them beyond coal to protect Clevelanders.

From realNEO:

Shock and Awe: House votes to eviscerate 40 years of bipartisan environmental safeguards

Submitted by Norm Roulet on Thu, 02/24/2011 - 10:30.

From the Environmental Defense Fund:

Shock and Awe: House votes to eviscerate 40 years of bipartisan environmental safeguards.
Fight moves to the Senate next week.

Please email your Senators today urging them to reject the polluter assault on our clean air and climate future.

Dear Friend,

You're going to breathe dangerous air, drink dirty water, be exposed to toxic pollution… And you're going to like it.

Oh, and you can forget about a safer climate future.

Example of Follow-up from President Obama visiting Cleveland: US Department of Energy Business Opportunity Sessions (BOS)

Submitted by Norm Roulet on Thu, 02/24/2011 - 01:58.

 

February 22, 2011, President Obama and senior staff visited Cleveland - joined by Department of Energy Secretary Steven Chu - to discuss how the Federal government may help small business grow... including in the energy sector. As an example of what small business owners may expect as next steps, you should subscribe to relevant U.S. government mailing lists like for the US Department of Energy Business Opportunity Sessions (BOS) - see link below. If you own a Women-Owned Small Businesses (WOSB) interested in energy, and government support, the following message is FOR YOU! This should be an exciting session and opportunity.

As you'll see, if you are a Small Disadvantaged Business, HUBZone;8(a), or Service-Disabled Veteran Owned small business, the DOE has specific Energy Business Opportunity Sessions (BOS) for you as well - subscribe for updates and good luck!

EPA Establishes Clean Air Act Standards for Boilers and Incinerators - What is the Impact in Northeast Ohio? Who Knows?!?!

Submitted by Norm Roulet on Wed, 02/23/2011 - 13:28.

Cleveland Thermal Pollution, Cuyahoga River, Cleveland, Ohio

There has been considerable conflict in industry and government - and Federal courts - over the emissions from large boilers and incinerators in America, and so Northeast Ohio, leading to new Clean Air Act standards for boilers and certain incinerators announced by the EPA today. As all America now acts to implement these new standards, it will be interesting to see what branches of government in Northeast Ohio monitor or even are aware of all the boilers and incinerators in this region - their current emissions and control technologies - which are out of compliance with the new standards - what they need to do to comply - what costs are involved to comply with the new act - what reductions in pollution will result, where - who will see reductions in their ambient and point source pollution - what benefits to public health will result - and how that will improve the value of property in this area. The public should be provided with this information immediately so we may make long term plans about where we live and what property we choose to own.

Battles over such rules are at the root of all evil in industry and America today - the heart of the tea party efforts to corrupt government by the Koch Brothers and their billionaire murderers and fans and followers in industries like coal and oil - The Fossil Boys - and the harm they have caused activists for clean energy, clean social networks like realNEO, the American people, and global climate. Thank you Federal EPA for your good fight for the health of Americans.

And you thought the tea party was actually about ending gays, abortion and unions! It was always all about the right to pollute and kill Americans! Time to end the party and fix America, everyone!

EPA Establishes Clean Air Act Standards for Boilers and Incinerators  

Sensible standards provide significant public health benefits while cutting costs from initial proposal by nearly 50 percentWASHINGTON – In response to federal court orders requiring the issuance of final standards, the U.S. Environmental Protection Agency (EPA) is issuing final Clean Air Act standards for boilers and certain incinerators that achieve significant public health protections through reductions in toxic air emissions, including mercury and soot, but cut the cost of implementation by about 50 percent from an earlier proposal issued last year.

Mercury, soot, lead and other harmful pollutants released by boilers and incinerators can lead to developmental disabilities in children, as well as cancer, heart disease, aggravated asthma and premature death in Americans. These standards will avoid between 2,600-6,600 premature deaths, prevent 4,100 heart attacks and avert 42,000 asthma attacks per year in 2014.

And if you had to pick a single “power plant” whose stack was spewing out the most smoke? U.S. Chamber of Commerce

Submitted by Norm Roulet on Tue, 02/22/2011 - 13:14.

Consider it a tale of two speeches and a grim parable for our American moment.

On March 24, 2010, Treasury Department Deputy Secretary Neil Wolin arrived for his lunchtime speaking slot at the U.S. Chamber of Commerce's impressive headquarters, a short walk from the Treasury building and the White House. When his time came, Wolin strode onstage and, before hundreds of its members, tore into the chamber and its policies. As an organization, it was dishonest and "backward," he said. An ongoing three-million-dollar lobbying campaign was not intended to bolster badly needed financial reforms on Wall Street, as claimed, but "designed to defeat them."

A stunned audience mustered only the weakest of applause. At the time, there was no love lost between the White House and the chamber.  Later that fall, with the help of a crucial Supreme Court decision, the group would act on that animosity, spending a staggering $33 million in the 2010 midterms and ushering in the biggest Republican landslide in generations.

Fast forward to Barack Obama's address to the chamber earlier this month. The president's appearance was cast as an “olive branch,” an attempt to smooth over a tumultuous relationship.  It lived up to the billing. "I’m here in the interest of being more neighborly,” Obama began. “Maybe if we would have brought over a fruit cake when I first moved in, we would have gotten off on a better foot. But I’m going to make up for it.”

The toughest the president got was when he pled with the chamber's corporate membership to "get in the game" and use trillions of dollars of reserves piled up in the worst of times for American workers to create much-needed jobs.

Dear President Obama, Thank you for coming to Cleveland to bring attention to environmental injustice in Northeast Ohio.

Submitted by Norm Roulet on Tue, 02/22/2011 - 11:30.

Dear President Obama,

Thank you for coming to Cleveland to bring attention to environmental injustice in Northeast Ohio.

I assume EPA Administrator Lisa Jackson has briefed you that, in addition to being the most lead poisoned big city in America, we are one of the most polluted, unhealthy, and so undereducated places on Earth.

As you ride into Downtown Cleveland - the most lead poisoned big city in America (the world?) - you pass one of the most environmentally unjust industrial facilities in America - Arcelor Mittal's Cleveland Works steel production and processing superfund site (AKA the Cuyahoga River Valley) - and, as you meet with Ohio taxpayer-funded business development agents here, you sit in the shadows of the privately-polluting Cleveland Thermal district coal plant (owned by some shadow out-of-state investors, it appears) immediately downtown... providing excessively polluting heat to the very Wolstein Center where you shall hold your small business conference today... "Cleveland Thermal’s largest customer is Cleveland State University (CSU)" (and they don't care).

Don't breathe too deeply here.

EPA Administrator Jackson and Department of Energy Director Chu may certainly tell you there are better ways to make steel and warm citizens, business development agents and the President of the United States of America than burning coal within 100s of yards of homes, offices and you.

Dear President Obama: Reading Material For Your Flight Home From Cancer-causing Cleveland

Submitted by Norm Roulet on Tue, 02/22/2011 - 09:08.

Research Article

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

María Salazar1,2, Arkaitz Carracedo1, Íñigo J. Salanueva1, Sonia Hernández-Tiedra1, Mar Lorente1,2, Ainara Egia1, Patricia Vázquez3, Cristina Blázquez1,2, Sofía Torres1, Stephane García4, Jonathan Nowak4, Gian María Fimia5, Mauro Piacentini5, Francesco Cecconi6, Pier Paolo Pandolfi7, Luis González-Feria8, Juan L. Iovanna4, Manuel Guzmán1,2, Patricia Boya3 and Guillermo Velasco1,2

1Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, Madrid, Spain.
2Centro de Investigación Biomédica en Red sobre Enfermedades Neurodegenerativas (CIBERNED), Madrid, Spain.
33D Lab (Development, Differentiation, and Degeneration), Department of Cellular and Molecular Physiopathology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.
4INSERM U624, Campus de Luminy, Marseille, France.
5National Institute for Infectious Diseases, IRCCS “L. Spallanzani,” Rome, Italy.
6Laboratory of Molecular Neuroembryology, IRCCS Fondazione Santa Lucia and Department of Biology, University of Rome “Tor Vergata,” Rome, Italy.
7Cancer Genetics Program, Beth Israel Deaconess Cancer Center and Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USA.
8Department of Neurosurgery, University Hospital, Tenerife, Spain.

Address correspondence to: Guillermo Velasco, Department of Biochemistry and Molecular Biology I, School of Biology, Complutense University, c/ José Antonio Novais s/n, 28040 Madrid, Spain. Phone: 34-913944668; Fax: 34-913944672; E-mail: gvd [at] bbm1 [dot] ucm [dot] es.

First published April 1, 2009
Received for publication November 3, 2008, and accepted in revised form February 11, 2009.

Autophagy can promote cell survival or cell death, but the molecular basis underlying its dual role in cancer remains obscure. Here we demonstrate that Δ9-tetrahydrocannabinol (THC), the main active component of marijuana, induces human glioma cell death through stimulation of autophagy. Our data indicate that THC induced ceramide accumulation and eukaryotic translation initiation factor 2α (eIF2α) phosphorylation and thereby activated an ER stress response that promoted autophagy via tribbles homolog 3–dependent (TRB3-dependent) inhibition of the Akt/mammalian target of rapamycin complex 1 (mTORC1) axis. We also showed that autophagy is upstream of apoptosis in cannabinoid-induced human and mouse cancer cell death and that activation of this pathway was necessary for the antitumor action of cannabinoids in vivo. These findings describe a mechanism by which THC can promote the autophagic death of human and mouse cancer cells and provide evidence that cannabinoid administration may be an effective therapeutic strategy for targeting human cancers.